A weighed amount of floating microspheres equivalent to 100 mg drug. Submit your final project report and get your work recognize by broad readership around the world. Mucoadhesive microspheres phd thesis proposal best essay. The percentage of floating microspheres was calculated by the following equation. Microspheres are considered to be one of the most promising floating systems, because they combine the advantages of multiple unit systems, good floating properties and are prepared using assorted polymers curatolo et al. Hollow microspheres are in strict sense, spherical empty particles without.
The drug release rates from floating microspheres were carried out using tablet dissolution test apparatus. Floating drug delivery system fdds, hpmc, ethyl cellulose, famotidine, invitro release. The collected microspheres were dried in desiccators. Development and evaluation of gastroretentive microspheres. The developed floating microspheres of famotidine may be used in clinic for prolonged drug release in stomach for at least 12 hrs, thereby improving the bioavailability and patient compliance. Scanning electron microscopy sem was performed to characterize the surface of formed beads. Ijert welcomes ug, master and phd thesis for publishing it online as a book with unique isbn. The aim of the current research work is to formulate and characterized the floating microspheres of glipizide. A weight of floating microspheres corresponding to 100 mg of drug was filled into a. Octoberdecember 20 research article ijpsn322rajkumar. Floating microspheres provide a constant and prolonged therapeutic effect which will reduce dosing frequency. Solid biodegradable microspheres incorporating a drug.
Solvent evaporation method the sodium alginate microspheres were prepared by solvent evaporation method reported by sahoo et al5 with some modifications. The floating microspheres was collected by decantation, while the nonfloating microspheres was discarded. The drug is released slowly at the desired rate, and the system is found to be floating on gastric content and increases gastric. In vitro floating properties of the metronidazole loaded microspheres were evaluated in a usp dissolution apparatus ii paddle type. The floating microspheres were collected by decantation, while the non floating microspheres were discarded along with any polymer precipitates. The floating thesis write or type out your working thesis on an index card or piece of paper. Microspheres are considered to be one of the most promising floating systems, because they combine. Floating microspheres are, in a strict sense, spherical empty particles without a. The drug entrapment efficiency of floating microspheres was found to be 81. The mean particle size of prepared floating microspheres increased but the drug release rate. Formulation and evaluation of floating beads of norfloxacin.
In the present investigation telmisartan floating tablets. Preparation and characterization of gastroretentive. Pdf formulation and evaluation of floating microspheres of. Sciences, karnataka shall have the rights to preserve, use and disseminate this dissertation thesis in. The microspheres was dried overnight at 402c and stored in desiccator 18. Floating microspheres thesis intech gelatin microspheres thesis. I hereby declare that the rajiv gandhi university of health. Formulation and characterization of floating microspheres of. Contents of the powerpoint on formulation and evaluation of microspheres include. Hollow microspheres are used as additives to lower the density of a material. Floating microspheres of prazosin hydrochloride was optimized by using central composite design. The glipizide floating microspheres with smooth surface was observed upon sem.
Gastroretentive floating microspheres are lowdensity systems that have. Floating microspheres are gastroretentive drug delivery systems based on a noneffervescent approach. The particle size of floating microsphere was found to be 483. Publish dissertation and thesis online as book ijert. Floating microspheres are prepared with enteric coated polymer sodium alginate successfully by the solvent evaporation technique. The collected microspheres were dried in desiccators over night. Hollow microspheres, microballoons or floating microparticles are terms used synonymously for. The percentage of microspheres was calculated by the following equation %floating microspheres weight of floating microspheres initial weight of floating microspheres. Floating microspheres were prepared by oilinwater emulsion solvent evaporation technique using ethyl cellulose and eudragit s100 as release retarding. Solvent evaporation method the sodium alginate microspheres were prepared by solvent evaporation method. The pdf preparation and characterization of gastroretentive floating. Oilin water emulsion is widely used due to simplicity of the process and easy cleans up requirement for the final product. Gastro retentive floating microspheres are low density systems that have sufficient buoyancy to float over the gastric contents and remain in stomach for prolonged period and slowly released the drug at desired rate with reduced fluctuations in plasmadrug concentration.
Preparation and characterization of gastroretentive mona semalty et al. Various formulation of floating microspheres of nateglinide formulation code drug mg ethyl cellulose mg eudragit s100 mg ethanol. Development and evaluation of floating microspheres of verapamil. Floating microspheres hollow microspheres are gastroretentive drug delivery systems based on noneffervescent approach. Thesis on floating microspheres 410876 akademik istatistik. Waterinoil emulsion technique was used to prepare the ciprofloxacin loaded gelatin microspheres and were. Hollow microspheres, microballoons or floating mic roparticles are terms used synonymously for floating microspheres. Floating microspheres19, 20 in floating types the bulk density is less than the gastric fluid and so remains buoyant in stomach without. Pdf the present study involves prepration and evaluation of. Floating microspheres thesis slideshare pdf phd thesis sunyhik ahn final requires a pdf viewer such as gsview xpdf or. Floating gastroretentive drug delivery systems based on.
Research article formulation and evaluation of floating. Microspheres are made from polymeric, waxy or protective materials that is biodegradable synthetic polymers and modified natural products. The recent developments of fdds including the physiological. Formulation and evaluation of floating beads of norfloxacin 9 3. Development of an oral delivery system to modulate the release of anthocyanins extracted from haskap berries lonicera caerulea l. These are freeflowing particles, with size ranging from 1 to m. Keywords serratiopeptidase, cholic acid, chitosan mucoadhesive microspheres 1. The paddles were rotated at 50 rpm and the temperature was maintained at 370. The microspheres were dried in an oven at 50 0c for. A 1% wv solution of sodium alginate was prepared in distilled water. Microspheres are manufactured in both solid and hollow form. Articles in pdf, epub and full text are attached to this page. Pdf preparation of mucoadhesivemicrospheres of atenolol by. It can be used for imaging liver metastases and also can be used to distinguish bowel loops from other abdominal structures by forming nano size particles supramagnetic iron oxides.
Preparation and evaluation of mucoadhesivemicrospheres of atenolol and propranolol patil p. Submission open for 2019 submit dissertation thesis online. Formulation and evaluation of gastroretentive floating. Floating drug delivery system ppt linkedin slideshare. Methods of preparation of floating microspheres floating microspheres can be prepared using any of the following techniques. Research paper preparation and characterization of. Gastric residence time of oral controlled release system such as microspheres is increase by different techniques such as floating and mucoadhesive system. Preparation and characterization of gastroretentive floating microspheres of 821 percent drug.
The layer of buoyant microspheres was pipetted and separated by filtration at 1, 2, 4 and 6 hours. Floating microspheres thesis high pressure processes group universidad. It can be used for imaging liver metastases and also can be used to distinguish bowel loops from other abdominal structures by forming nano size particles. Hollow microspheres, microballoons or floating microparticles are terms used synonymously for floating microspheres. Effect of processing parameters on semicrospheres 34 4. The drug release rate from floating microspheres was carried out using the usp type ii electro lab. Pdf floating microspheres as drug delivery system researchgate. Optimization and evaluation of prazosin hydrochloride. A weight of floating microspheres corresponding to 100 mg of drug was filled into a capsule and placed in basket. Evaluation parameters particle size analysis particle size and shape of the microspheres was determined by optical microscopy. The best results were obtained at the ratio of drug.
The purpose of this study was to develop and evaluate metronidazole loaded floatingmucoadhesive microsphere for sustained drug release at the gastric mucosa. Preparation and characterization of gastroretentive floating microspheres of 821 percent drug loading ofloxacin hydrochloride content in the thesis on floating microspheres 458228thesis on floating microspheres 458228. Waterinoil emulsion technique was used to prepare the ciprofloxacin loaded gelatin microspheres and were then impregnated in the collagen sponge4. Formulation, optimization and evaluation of floating.
In this study, a threefactors, three levels centralcomposite design with drugpolymer ratiox1, solvent. Formulation composition of telmisartan floating tablets. Introduction microspheres can be defined as solid, spherical, free flowing, smooth surface particles ranging in size from 1 to 4m. The percentage of floating microspheres was calculated by. Development of floatingmucoadhesive microsphere for site. Microencapsulation is one of the quality preservation techniques of sensitive substances and a method for production of materials with new valuable properties. These are gastro retentive drug delivery dosage systems grdds based on noneffervescent approach. Floating microspheres were collected at 4,8 and 12 hrs and dried till constant weight was obtained. The mean particle size of prepared floating microspheres increased but the drug release rate from the microspheres decreased as the polymer concentration increased. The floating microspheres of cefixime were prepared with this objective using the biocompatible natural polymers like alginate and chitosan by ionotropic gelation method. A weighed amount of floating microspheres of cp were filled into a capsule and placed in the basket. The floating microspheres were collected by decantation, while the nonfloating microspheres were discarded. Conclusions of the characterization of semicrospheres 38 4. Development and in vitro characterization of esomeprazole.
Floating behavior of floating microsphere12,37 100 mg of the floating microsphere were placed in 0. A weighed amount of floating microspheres equivalent to 100 mg drug were dispersed in 900 ml of 0. Ijert welcomes ug, master and phd thesis for publishing it online as a book with unique. Glipizide administered in a dose of 520 mg in once or twice daily. Figure schematic overview of composite magnetic microsphere preparation a drug loading. Cellulose acetate, acrycoat s100 and eudragit s100 microspheres loaded with verapamil hydrochloride were prepared by solvent diffusion evaporation method.
Floating microspheres are, in a strict sense, spherical empty particles without a core. Upon incorporation of the hydrophilic polymer, such as hpmc i the shell of microspheres, the amount of drug released from microspheres could be enhanced. The entrapment efficiency of prepared floating microspheres was satisfactory 41. Preparation of microspheres of losartan potassium using natural polymers method used. Formulation and characterization of floating microspheres. Formulation and optimization of floating microspheres of. Preparation and evaluation of floating microspheres of. Float it down next to each paragraph in the body of your draft and ask yourself these questions. The microspheres were dried in an oven at 50 0c for 2h, weighed and then stored in a desiccator at room temperature till further use. To develop and evaluate therapeutic potential of noval carriers. Submission open for 2019 submit dissertationthesis online.
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